While we might be tempted to speak in terms of competing substances when it comes to the healing properties of marijuana, the truth is that what makes cannabis so remarkable on so many fronts is the senergy which seems to occur between all the substances it contains.
Ever since visionary cannabinoid researcher Raphael Mechoulam began writing about the “Surround effect” of cannabis in the mid-1990s, science is learning more and more about how each molecular component of the cannabis plant works together for healing on a multitude of levels. This is true for the state these substances are also found. Both THC-A and CBD-A are found in the natural, raw, live cannabis plant. And recent research has found that both have powerful properties of their own when it comes to treating disease, especially cancer.
What are THC-A and CBD-A?
Cannabidolic acid (CBD-A) and tetrahydrocannabonolic acid (THC-A) are similar in many ways. Both are acid-based substances found in the live, raw cannabis plant. Both are completely non-psychoactive. And both convert to their counterparts – CBD and THC respectfully – when heated above a certain temperature (approximately between 200 and 290 F for THC-A and between 240 and 290 F for CBD -AT).
The process by which these “A” substances can transform into their better known counterparts is called decarboxylation.. This is because both THC-A and CBD-A lose carbon atoms to form THC and CBD when heated. The most common way of decarboxylation is through smoking or vaping, although cooking and baking cannabis, as with making edibles, stimulates decarboxylation as well as.
THC-A and CBD-A are similar in one more important way: these two cannabinoids can help cure some of the most serious diseases.
The cancer healing power of CBD-A
CBD-A has been in the news a lot lately, mostly for the new ways it has been shown to inhibit cancer. The link between cancer and CBD-A was catalyzed by a 2012 study who examined the effect of CBD-A on breast cancer cells. This and subsequent studies have found that CBD-A in raw cannabis can suppress the COX-2 enzyme, a major instigator of breast cancer metastasis, as well as other forms of cancer.
the latest studypublished in January 2017 in the journal of natural medicine by researchers at the International University of Hiroshima, sheds additional light on the subject. Researchers have discovered a possible way in which CBD-A inhibits the COX-2 enzyme in very aggressive breast cancer tumors. Their study focused on CBD-A’s inhibition of proto oncogene c-Fosa common precursor of proteins involved in cancer metastasis.
CBD-A as well as THC-A have also been known for some time for their anti-inflammatory effects; in fact, that’s a big part of what makes it a potential cancer killer. A 2011 Swedish study rated six different cannabinoids—CBD-A and THC-A as well as THC, CBD, CBDA, CBG and CBGA– for their effects on inflammatory processes, including COX-2. They found that these six substances together had a profound effect on inflammatory processes in colon cancer cell lines in the laboratory. According to the researchers:
“Endocannabinoids are structurally similar to arachidonic acid and have been suggested to interfere with the inflammatory process. They have also been shown to inhibit cancer cell proliferation.
Arachidonic acid is an omega-6 fatty acid that is necessary in the body for brain health and the general functioning of almost all body systems. It’s a antioxidant and mediator of harmful inflammatory reactions such as those that occur with serious diseases like cancer. The discovery through study of endocannabinoid structures similar to those of other healing substances in the body is exciting. This is further proof of the ability of cannabis to balance the endocannabinoid system for overall disease healing.
THC-A: A powerful and ever-mysterious healer
While there is still a lot of research to be done on CBD-A, there are even more mysteries about THC-A, the non-psychoactive raw form (prior to decarboxylation). of THC. The Swedish study mentioned above as well as a few other studies have however proven that THC-A is also a powerful anti-inflammatory. As such, it is also believed to have anti-proliferative effects against cancer growth and metastasis. It is also a recognized neuro-protector, an antispasmodic and a powerful endocannabinoid against pain.
THC-A has also been shown to be an immune system regulator. According to the latest scientific findings, THC-A affects the endocannabinoid system as a whole, not just the CB1 receptors. THC-A can affect the release of the inflammatory enzymes COX-1 and COX-2 as well as TNF-Alpha. It also helps in the production of interleukin-10. This potent anti-inflammatory cytokine, also known as human cytokine synthesis inhibitory factor (CSIF), is produced by T cells of the immune system.
While CBD has been known for some time for its effects on epilepsy and seizures, and in recent years ∆9-THC has proven helpful, new research indicates The benefits of THC-A on this front as well. Among the most recent surveys was a study conducted by the University of Alabama and published in the January 10, 2017 edition of the medical journal Epilepsy and behavior.
More research is needed on CBD-A and THC-A
The research that exists on the health benefits of CBD-A and THC-A, particularly in relation to cancer, provides great news for those who want to heal with cannabis but whose systems may not respond. positively to psychoactive effects. of THC. Hopefully, with more states opening their doors to medical marijuana (the whole plant, not just CBD) and with research funding in states like Colorado starting to arrive, more attention will be given to substances that exist in the natural, raw cannabis plant. , like CBD-A and THC-A as well.
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